The group of blistering reactions includes Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are considered as one disease entity of different severity and are also referred to as “Epidermal” or “Epithelial Necrolysis” (EN). The group of drug reactions with primarily systemic involvement is represented by a condition known as “drug reaction with eosinophilia and systemic symptoms” (DRESS).

Not all reaction types are clearly drug-induced, as infections may also result in MPE or EN in children. Thus, the causative agent can only be identified in about 50% of all paediatric EN cases. Once the diagnosis is established, specific therapies should primarily entail the withdrawal of the causative agent, which requires a thorough medication history. Antibiotics are a frequent cause of MPE in children, whereas paracetamol may induce FDE. Certain antiepileptic drugs, antibacterial sulfonamides and sulfasalazine are among the most common triggers of EN and DRESS, respectively, in children.